Functional genomics to explore cancer cell vulnerabilities
نویسندگان
چکیده
منابع مشابه
Using functional genomics to explore the effects of ocean acidification on calcifying marine organisms
As the research community attempts to forecast the effects of ocean acidification on marine ecosystems, a critical element is a clear understanding of the effects of ocean acidification on an individual organism’s physiology. This article explores how the use of genomics-based tools that measure gene expression — DNA microarrays and quantitative PCR — can assist in this effort and reveal aspect...
متن کاملUsing functional magnetic resonance imaging (fMRI) to explore brain function: cortical representations of language critical areas
Pre-operative determination of the dominant hemisphere for speech and speech associated sensory and motor regions has been of great interest for the neurological surgeons. This dilemma has been of at most importance, but difficult to achieve, requiring either invasive (Wada test) or non-invasive methods (Brain Mapping). In the present study we have employed functional Magnetic Resonance Imaging...
متن کاملUtilizing high-throughput genomics methodologies to explore transcritomes and exomes
ii ACKNOWLEDGEMENTS The work in this thesis would not have been possible without the aid of a great many people, most importantly my research advisor, Professor John Manak. When I did my second rotation more than four years ago, John showed his great kindness and patience by answering all of my questions regarding the project I was working on. It was his kindness and patience that made me decid...
متن کاملSquamous cell lung cancer: from tumor genomics to cancer therapeutics.
Squamous cell lung cancer (SCC) represents an area of unmet need in lung cancer research. For the past several years, therapeutic progress in SCC has lagged behind the now more common non-small cell lung cancer histologic subtype of adenocarcinoma. However, recent efforts to define the complex biology underlying SCC have begun to bear fruit in a multitude of ways, including characterization of ...
متن کاملUtilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent that more complex models of cancer are required to fully appreciate the contributing factors that drive tumorigenesis in vivo and increase the efficacy of novel therapies th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurosurgical Focus
سال: 2010
ISSN: 1092-0684
DOI: 10.3171/2009.10.focus09212